Lupus Star Foundation

Shining Bright for Lupus

News

view:  full / summary

Walkin' Talkin' Lupus

Posted by Simone on June 5, 2013 at 4:30 PM Comments comments (0)

Walkin' Talkin' Lupus (WTL) is a new weekly walking group created by the Lupus Star Foundation to bring together lupus survivors in a healthy, adventurous way. The group will participate in various activities, all while building the strong support network that lupus patients need. The main goal of Walkin' Talkin' Lupus is to allow lupus survivors to connect with one another, share lupus information, as well as personal issues, stories and advice; in a fun, healthy way.  WTL will attend local events and participate in activities such as visiting museums, dining together, walking, taking boat rides and the occasional round of mini golf.  A traditional support group where you sit in a room and have discussions is great, but our group is the next level of therapy.  Enjoying and connecting with your support network  in a fun and exciting way is good for the patients' physical, mental and emotional well-being.  The group is open to people with other chronic illnesses and supporters as well.  Our main activity will be walking the downtown Detroit area. This promotes good health and allows lupus patients to connect in a unique way. 


Lupus warriors and supporters take a leisurely walk together for exercise and good health, but more importantly to connect, learn from and support one another. Just think of it as a support group, walking club and girl's day out all in one!! Men are welcome too! Bring your families along, a good walk is great for everybody's health. We will stroll the river walk beginning at Milliken State Park (Atwater St and Rivard), we will meet near the carousel. Please let us know if you plan to attend by email, Twitter or Facebook. 


Information about the WTL events will always be posted in the LSF events calendar, and can also be found on the site homepage. The first Walk is scheduled for Sunday June 30th at 6pm. More details can be found on the events calendar. Please tweet @lupusstar or email [email protected] any questions or concerns. We encourage all Lupus patients in the Metro Detroit Area to join Walkin' Talkin' Lupus, no matter how serious your illness is!! We need you, as much as you need us!!

WEAR PURPLE OR ORANGE!!

When The Healing Element Is Also The Enemy: Medical Enigma Probed

Posted by Simone on June 5, 2013 at 3:10 PM Comments comments (0)

By Hebrew University Researchers
05 Apr 2013


The same factor in our immune system that is instrumental in enabling us to fight off severe and dangerous inflammatory ailments is also a player in doing the opposite at a later stage, causing the suppression of our immune response.


Why and how this happens and what can be done to mediate this process for the benefit of mankind is the subject of an article published online in the journal Immunity by Ph.D. student Moshe Sade-Feldman and Prof. Michal Baniyash of the Lautenberg Center for General and Tumor Immunology at the Institute for Medical Research Israel-Canada at the Hebrew University Faculty of Medicine.


Chronic inflammation poses a major global health problem and is common to different pathologies -- such as autoimmune diseases (diabetes, rheumatoid arthritis, lupus and Crohn's), chronic inflammatory disorders, chronic infections (HIV, leprosy, leishmaniasis) and cancer. Cumulative data indicate that at a certain stage of each of these diseases, the immune system becomes suppressed and results in disease progression.


In their previous work, the Hebrew University researchers had shown that in the course of chronic inflammation, unique immune system cells with suppressive features termed myeloid derived suppressor cells (MDSCs) are generated in the bone marrow and migrate into the body's organs and blood, imposing a general immune suppression.


A complex network of inflammatory compounds persistently secreted by the body's normal or cancerous cells support MDSC accumulation, activation and suppressive functions. One of these compounds is tumor necrosis factor-a (TNF-a), which under acute immune responses (short episodes), displays beneficial effects in the initiation of immune responses directed against invading pathogens and tumor cells.


However, TNF-a also displays harmful features under chronic responses, as described in pathologies such as rheumatoid arthritis, psoriasis, type II diabetes, Crohn's disease and cancer, leading to complications and disease progression. Therefore, today several FDA- approved TNF-a blocking reagents are used in the clinic for the treatment of such pathologies.


What has remained unclear until now, however, is just how TNF-a plays its deleterious role in manipulating the host's immune system towards the generaation of a suppressive environment.


In their work, the Hebrew University researchers discovered the mechanisms underlying the TNF-a function, a key to controlling this factor and manipulating it, perhaps, for the benefit of humans. Using experimental mouse models, they showed unequivocally how TNF-a is critical in the induction of immune suppression generated during chronic inflammation. The TNF-a was seen to directly affect the accumulation and suppressive function of MDSCs, leading to an impaired host's immune responses as reflected by the inability to respond against invading pathogens or against developing tumors.


Further, the direct role of how TNF-a works in humans was mimicked by injecting the FDA-approved anti-TNF-a drug, etanercept, into mice at the exacerbated stage of an inflammatory response, when MDSC accumulation was observed in the blood. The etanercept treatment changed the features of MDSCs and abolished their suppressive activity, leading to the restoration of the host's immune function.


Taken together, the results show clearly how the TNF-a-mediated inflammatory response, whether acute or chronic, will dictate its beneficial or harmful consequence on the immune system. While during acute inflammation TNF-a is vital for immediate immune defense against pathogens and clearance of tumor cells, during chronic inflammation -- under conditions where the host is unable to clear the pathogen or the tumor cells -- TNF-a is harmful due to the induction of immune suppression.


These results, providing new insight into the relationship between TNF-a and the development of an immune suppression during chronic inflammation, may aid in the generation of better therapeutic strategies against various pathologies when elevated TNF-a and MDSC levels are detected, as seen, for example, in tumor growths.

June Health Awareness

Posted by Simone on June 14, 2011 at 1:52 AM Comments comments (0)

☀ Men's Health Month

☀ Home Safety Month

☀ National Aphasia Awareness Month

☀ Cataract Awareness Month

☀ National Scleroderma Awareness Month

☀ National Cancer Survivor's Day (5)

☀ World Sickle Cell Day (19)

☀ National HIV Testing Day (27)

☀ Men's Health Week (13-19)


Volunteers Needed!!

Posted by Simone on May 28, 2011 at 9:07 PM Comments comments (0)

We need dedicated lupus supporters to help us out with our lupus awareness booth at various summer festivals.  The first festival will be on Saturday June 4th in Ann Arbor, MI.  The second is July 1-4th. Please let us know if you would like to help out.  Your support and assistance will be greatly appreciated.  Please email [email protected] if you would like to help us!!

Remember that our peer support group meeting is scheduled for June 5th in Ypsilanti!! All chronic illness sufferers, supporters, friends and family are invited.  Refreshments and light snacks will be served. Please join us to support each other and share valuable experiences and information.



Our Spring Newsletter is out!!

Posted by Simone on May 19, 2011 at 8:26 PM Comments comments (0)

We have released our 4th issue of the Lupus Star Newsletter!! Check it out here --> https://acrobat.com/#d=RHVvDeBeH7h7u-riZIxvXw

You can also download this newsletter and the other issues, as well as great lupus info on our Lupus Info page -->  http://lupusstar.org/apps/documents

If you would like to subscribe to the newsletter and receive it by mail free of charge please email your name, address, and phone number to [email protected]  

Thank you for reading and enjoy!!


SLE: New Test Could Give SLE Patients a More Tolerable Life

Posted by Simone on May 11, 2011 at 9:45 PM Comments comments (0)

ScienceDaily (May 9, 2011) — Five million people worldwide suffer from the chronic rheumatic disease SLE, systemic lupus erythematosus. Together with rheumatologists, researchers at Lund University in Sweden are on the way to developing a new test that could resolve a number of question marks surrounding the disease and in the long run improve the lives of SLE patients.

Their research is published in the next issue of the journal Molecular and Cellular Proteomics.

"At present, it can take up to a year before a patient is diagnosed with SLE. This is because the symptoms are diffuse and are often mistaken for other diseases. However, with this blood-based test, it is possible to determine quickly whether someone has the disease or not," says Christer Wingren, associate professor in Immunotechnology at CREATE Health, Lund University.


The test can also determine how far the disease has progressed. There are three different variants of SLE, and all require different treatment. With current methods, it is often difficult to find out which variant a patient has, which makes it difficult for doctors to prescribe the right medication. A third advantage of the new technique is that it also makes it possible to predict when the disease will become active.


"Characteristic of SLE is that the disease goes in waves, or flares. Without warning, the disease can flare up and put the patient out of action for a long time. With our test, we hope to be able to predict when an episode is about to happen and in this way prevent it using the right medication," explains Christer Wingren.


If all goes well, hospitals could start using the technique in two to three years.

The test itself comprises a small chip, smaller than a little fingernail, on which the researchers create a grid pattern, known as an array, using specially selected antibodies. The antibodies serve as 'capture molecules'; by placing a drop of blood on the chip, the antibodies bind the proteins, or biomarkers, in the body. In this way, a unique 'fingerprint' is produced for each patient, which reflects the disease.


"In our article, we show which pattern of biomarkers (the 'fingerprint') to look for. From a technical point of view, we get a large number of data signals that say whether the marker is present and in what quantity. These measurements are then entered into a computer, which can present them to the doctors in a way that is easy to understand. It is this fingerprint which doctors could use in the future in clinical practice," explains Christer Wingren, who has spent most of the past decade developing the technique, and the past two years adapting it for SLE in particular.


According to Christer Wingren, a number of researchers around the world have attempted to develop something similar, but without success. The Lund researchers' success in the task is partly due to them having found a way to make the antibodies stable and thus more functional. The method has also become highly sensitive.

 

In order for the research to benefit patients, a number of key biomarker signatures, which form the basis for the test, have been patented. The findings have also been transferred to a newly started company, Immunovia, which was founded by Christer Wingren and three of his colleagues at the Department of Immunotechnology.


The research has its origins in the cancer research that Christer Wingren and a number of other researchers at the translational cancer centre CREATE Health work on. Together with Carl Borrebaeck, Dr Wingren uses an equivalent technological platform that can detect and diagnose different types of cancer. They have very promising data for predicting breast cancer recurrence and diagnosing pancreatic cancer.

The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Lund University, via AlphaGalileo.

May 10th is World Lupus Day

Posted by Simone on May 10, 2011 at 11:19 AM Comments comments (0)

World Lupus Day began with a Proclamation 7 years ago by an international steering committee representing lupus organizations from 13 different nations when they met in Eaton, United Kingdom to organize the first observance of World Lupus Day. The Proclamation is a call to action for governments around the world to increase their financial support for lupus research, awareness and patient services.

The Proclamation reflects the emerging issues that people with lupus around the world must face every day. The Proclamation serves to give a single voice to all individuals affected by this devastating and debilitating chronic disease.


www.worldlupusday.org


Methotraxate Induced Hair Loss

Posted by Simone on April 20, 2011 at 1:22 AM Comments comments (0)

How does methotrexate induce hair loss?

To understand methotrexate induced hair loss, let us first understand the life cycle of a hair. Hair is made by a hair follicle. Each hair has a growth phase known as anagen & a resting phase known as telogen. A hair follicle grows hair for upto 3- 4 years. This is the end of the life cycle of the hair. It falls, the follicle then rests for about 3- 4 months & starts making a new hair. Normally most scalp hair (about 85%) are in the growth phase & only about 100 scalp hair fall every day. Methotrexate triggers a process called telogen effluvium wherein a greater proportion of hairs suddenly enter the resting phase. The hair thus stops growing & fall out.

How can one take care of methotrexate induced hair loss?

  • Avoid scalp massage.
  • Adopt a shorter hairstyle for the time being to make your hair look thicker until it grows in again.
  • Do not blowdry or straighten hair too often. The heat damages the hair proteins & makes them fragile.
  • Do not brush while you while you blow-dry them.
  • Use a good conditioner.
  • Maintain a good diet. Vitamin deficiencies will add up to the hair loss.
Is there any treatment for methotrexate induced hair loss?

Biotin is a vitamin involved in hair growth and associated with healthy skin and nails. Biotin supplements do help in methotrexate induced hair loss.

Volunteers Needed!!

Posted by Simone on April 16, 2011 at 2:00 PM Comments comments (0)

Lupus Star Foundation is proud to announce that we have a volunteer opportunity this spring and summer. We will assist CCC Because We Care Foundation with their volunteer program with the Detroit Tigers. We will work the concessions during the 2011 Tigers season and earn money for Lupus Star Foundation. We need as many people to volunteer as possible. The more games we work and the more people we have at the games, the more money we will have donated to us. LSF really needs your help!!!

There are 30 games that we can volunteer for, but you can work as many or as few as you would like. Regardless if you plan to work 1 or 25 games, you are required to attend training.  You must be 18 years and older. May training sessions are on Monday, May 9th from 6-9pm, and Thursday, May 19th from 6-9pm. You can attend either day. We began working games on Friday, April 22, 2011 and we will work through Wednesday, September 28, 2011.  If you are interested please let me know as soon as possible. Also, please pass this on to your family, friends and supporters. Email, call, text, post it to your Facebook and Twitter account, whatever you have to do to get volunteers. Anyone can help out!!

If you would like to get involved, but this is not the program for you, please contact us. If you would like to donate to the foundation please do so oon our donations page.

Email: [email protected] or call us at (734) 274-4632

Online Donation System is Here

Posted by Simone on April 16, 2011 at 1:47 PM Comments comments (0)

Our online donation system is now up and running.  Please take the time to donate to our cause.  We cannot do anything without your help.  We are currently working on an awareness campaign, beginning a support group, and organizing several events.  Without your donations we will not be able to accomplish our goals.  

Please forward your friends, family and other lupus supporters to our website and donations page.  Every cent counts.  We are looking forward to organizing great services and events to you all.   

To donate please visit our donations page.  Credit and debit cards, and bank and Paypal accounts are all accepted.  You can donate even if you do not have a Paypal account.  

Let's continue to spread Hope & Love 4 Lupus!! 



Rss_feed

Upcoming Events

Sunday, Aug 27 at 6:00 PM - 7:30 PM
Sunday, Sep 3 at 6:00 PM - 7:30 PM
Sunday, Sep 10 at 6:00 PM - 7:30 PM
Sunday, Sep 17 at 6:00 PM - 7:30 PM
Share on Facebook

Hope & Love 4 Lupus Campaign

Google Translator